The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis.

Journal article

The 5-HTTLPR polymorphism has been widely regarded as a potential genetic risk factor for affective disorders. Consistent with this, this polymorphism has been associated with altered amygdala responses at rest and in response to aversive stimuli. However, the strength of this association remains uncertain. We sought to synthesize existing data on the association between the 5-HTTLPR polymorphism and amygdala activation and ascertain the strength of evidence for this association. Meta-analyti...

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Authors: Murphy, SE; Norbury, R; Godlewska, B; Cowen, P; Mannie, Z

• Publication status: Published
• Journal: Molecular psychiatry
• Volume: 18
• Issue: 4
• Pages: 512-520
• Publication date: 2013-04-01
• DOI: 10.1038/mp.2012.19
• EISSN: 1476-5578
• ISSN: 1359-4184
• Language: English
• Keywords: Functional Neuroimaging; Adult; Male; Functional Laterality; Genetic Association Studies; Amygdala; Psychomotor Performance; Publication Bias; Serotonin Plasma Membrane Transport Proteins; Humans; Female; Polymorphism, Genetic