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Thesis

Comparison of different therapies for neonatal diabetes – glibenclamide vs insulin

Abstract:

Gain-of-function mutations in the Kir6.2 and SUR subunits of the KATP channel are associated with neonatal diabetes (ND). I used a mouse model selectively expressing the Kir6.2-V59M mutation in pancreatic β-cells (inducible iβ-V59M) to compare the effects of sulphonylurea and insulin therapy on neonatal diabetes. Gene expression was induced in adulthood, which caused severe hyperglycaemia and resulted in a major decrease in insulin content, pancreatic β-cell area, pancreatic islet number, ...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
St Anne's College
Role:
Author

Contributors

Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Publication date:
2012
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:e2e7464f-7be9-4d78-a0a9-775e73b6760f
Local pid:
ora:7436
Deposit date:
2013-10-09

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