Thesis
Comparison of different therapies for neonatal diabetes – glibenclamide vs insulin
- Abstract:
-
Gain-of-function mutations in the Kir6.2 and SUR subunits of the KATP channel are associated with neonatal diabetes (ND). I used a mouse model selectively expressing the Kir6.2-V59M mutation in pancreatic β-cells (inducible iβ-V59M) to compare the effects of sulphonylurea and insulin therapy on neonatal diabetes. Gene expression was induced in adulthood, which caused severe hyperglycaemia and resulted in a major decrease in insulin content, pancreatic β-cell area, pancreatic islet number, ...
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Authors
Contributors
+ Ashcroft, F
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:e2e7464f-7be9-4d78-a0a9-775e73b6760f
- Local pid:
- ora:7436
- Deposit date:
- 2013-10-09
Terms of use
- Copyright holder:
- Iberl, M
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available in ORA.
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