Thesis
Atomistic studies of the dynamics of P-glycoprotein and its ligands
- Abstract:
-
A signifficant obstacle facing the healthcare industry is the phenomenon of multidrug resistance (MDR) in which a cell acquires simultaneous resistance to many unrelated drugs that it has never been exposed to. At the molecular level, MDR can be characterised by a reduction of intracellular drug levels due to their active efflux by multidrug transporters such as P-glycoprotein (Pgp). Pgp is able to efflux a phenomenally wide variety of chemically unrelated drugs and causal relationships ha...
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Authors
Contributors
+ Biggin, P
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
+ Schnell, J
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:e2e2bbe0-d4ae-4351-b339-c8e02ef3d3d9
- Local pid:
- ora:11827
- Deposit date:
- 2015-07-09
Terms of use
- Copyright holder:
- Jerome Ho Yin Ma
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available via ORA.
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