- Abstract:
-
A signifficant obstacle facing the healthcare industry is the phenomenon of multidrug resistance (MDR) in which a cell acquires simultaneous resistance to many unrelated drugs that it has never been exposed to. At the molecular level, MDR can be characterised by a reduction of intracellular drug levels due to their active efflux by multidrug transporters such as P-glycoprotein (Pgp). Pgp is able to efflux a phenomenally wide variety of chemically unrelated drugs and causal relationships ha...
Expand abstract - Role:
- Supervisor
- Role:
- Supervisor
- Institution:
- University of Oxford
- Oxford college:
- Lincoln College
- Department:
- Medical Sciences Division - Biochemistry
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
-
uuid:e2e2bbe0-d4ae-4351-b339-c8e02ef3d3d9
- Local pid:
- ora:11827
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Jerome Ho Yin Ma
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available via ORA.
Thesis
Atomistic studies of the dynamics of P-glycoprotein and its ligands
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Authors
Contributors
+ Phil Biggin
+ Jason Schnell
+ Jerome H.Y. Ma
Funding
Bibliographic Details
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