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Thesis

Atomistic studies of the dynamics of P-glycoprotein and its ligands

Abstract:

A signifficant obstacle facing the healthcare industry is the phenomenon of multidrug resistance (MDR) in which a cell acquires simultaneous resistance to many unrelated drugs that it has never been exposed to. At the molecular level, MDR can be characterised by a reduction of intracellular drug levels due to their active efflux by multidrug transporters such as P-glycoprotein (Pgp). Pgp is able to efflux a phenomenally wide variety of chemically unrelated drugs and causal relationships ha...

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Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Lincoln College
Role:
Author
More by this author
Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
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Funding agency for:
Ma, J
Grant:
ALRQMC0
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:e2e2bbe0-d4ae-4351-b339-c8e02ef3d3d9
Local pid:
ora:11827
Deposit date:
2015-07-09

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