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Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells.

Abstract:

Modified vaccinia Ankara-expressing Ag85A (MVA85A) is a new tuberculosis (TB) vaccine aimed at enhancing immunity induced by BCG. We investigated the safety and immunogenicity of MVA85A in healthy adolescents and children from a TB endemic region, who received BCG at birth. Twelve adolescents and 24 children were vaccinated and followed up for 12 or 6 months, respectively. Adverse events were documented and vaccine-induced immune responses assessed by IFN-gamma ELISpot and intracellular cytok...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200939754

Authors


Scriba, TJ More by this author
Tameris, M More by this author
Mansoor, N More by this author
van der Merwe, L More by this author
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Journal:
European journal of immunology
Volume:
40
Issue:
1
Pages:
279-290
Publication date:
2010-01-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:e2e2b141-5389-42d2-ad71-a65ab8bd92dd
Source identifiers:
48503
Local pid:
pubs:48503

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