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A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers

Abstract:

Background

Despite much progress in cancer research, its incidence and mortality continue to rise. A robust biomarker that would predict tumor behavior is highly desirable and could improve patient treatment and prognosis.

Methods

In a retrospective bioinformatics analysis involving patients with liver cancer (n = 839), we developed a prognostic signature consisting of 45 genes associated with tumor-infiltrating lymphocytes and cellular r...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1186/s12967-019-1775-9

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
ORCID:
0000-0001-8960-8095
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Journal of Translational Medicine Journal website
Volume:
17
Issue:
14
Publication date:
2019-01-09
Acceptance date:
2019-01-04
DOI:
EISSN:
1479-5876
Pubs id:
pubs:959299
URN:
uri:e2db5771-5ec6-4cd2-abef-10a2735d7609
UUID:
uuid:e2db5771-5ec6-4cd2-abef-10a2735d7609
Local pid:
pubs:959299

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