- Abstract:
-
The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. We found that the transition to seizure is not a sudden phenomenon, but is instead a slow process that is characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural pheno...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 964.8KB)
-
- Publisher copy:
- 10.1038/s41593-018-0278-y
-
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Neuroscience Journal website
- Volume:
- 21
- Pages:
- 1742–1752
- Publication date:
- 2018-11-26
- Acceptance date:
- 2018-10-19
- DOI:
- EISSN:
-
1546-1726
- ISSN:
-
1097-6256
- Pubs id:
-
pubs:948280
- URN:
-
uri:e2d14812-170f-469f-a619-372fb4b2004c
- UUID:
-
uuid:e2d14812-170f-469f-a619-372fb4b2004c
- Local pid:
- pubs:948280
- Language:
- English
- Copyright holder:
- Chang et al.
- Copyright date:
- 2018
- Notes:
- © The Author(s), under exclusive licence to Springer Nature America, Inc. 2018. This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41593-018-0278-y
Journal article
Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
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