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Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Abstract:

The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. We found that the transition to seizure is not a sudden phenomenon, but is instead a slow process that is characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural pheno...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41593-018-0278-y

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Role:
Author
ORCID:
0000-0003-2339-5757
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Role:
Author
ORCID:
0000-0003-1402-1470
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Funding agency for:
Jefferys, JGR
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Funding agency for:
Jefferys, JGR
Publisher:
Springer Nature Publisher's website
Journal:
Nature Neuroscience Journal website
Volume:
21
Pages:
1742–1752
Publication date:
2018-11-26
Acceptance date:
2018-10-19
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
Pubs id:
pubs:948280
URN:
uri:e2d14812-170f-469f-a619-372fb4b2004c
UUID:
uuid:e2d14812-170f-469f-a619-372fb4b2004c
Local pid:
pubs:948280
Language:
English

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