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The assessment of antimalarial drug efficacy.

Abstract:

Antimalarial drug efficacy in uncomplicated malaria should be assessed parasitologically in large, community-based trials, enrolling the age groups most affected by clinical disease. For rapidly eliminated drugs, a 28-day follow-up is needed, but, for slowly eliminated drugs, up to nine weeks could be required to document all recrudescences, and, when possible, the drug levels should also be measured. The WHO 14-day assessments are neither sensitive nor specific. In tropical Plasmodium vivax ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
Journal:
Trends in parasitology
Volume:
18
Issue:
10
Pages:
458-464
Publication date:
2002-10-05
DOI:
EISSN:
1471-5007
ISSN:
1471-4922
URN:
uuid:e2cd5136-e38c-41b7-81e7-63c2c18ac91d
Source identifiers:
95513
Local pid:
pubs:95513

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