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Measurement error, time lag, unmeasured confounding: considerations for longitudinal estimation of the effect of a mediator in randomised clinical trials

Abstract:

Clinical trials are expensive and time-consuming and so should also be used to study how treatments work. This would allow evaluation of theoretical treatment models and refinement and improvement of treatments. Treatment processes can be studied using mediation analysis. Randomised treatment makes some of the assumptions of mediation models plausible, but the mediator – outcome relationship remains one that can be subject to bias. In addition, mediation is assumed to be a temporally ordered ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/0962280216666111

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Institution:
University of Oxford
Oxford college:
St Cross College
Role:
Author
Department for Work and Pensions More from this funder
Medical Research Council More from this funder
Department for Health for England More from this funder
The Scottish Chief Scientist Office More from this funder
Publisher:
SAGE Publications Publisher's website
Journal:
Statistical Methods in Medical Research
Publication date:
2016-09-19
Acceptance date:
2016-08-04
DOI:
EISSN:
1477-0334
ISSN:
0962-2802 and 1477-0334
Source identifiers:
638853
EISBN:
Keywords:
Pubs id:
pubs:638853
UUID:
uuid:e2cb5c9a-3661-4a84-be5e-816e453eea9b
Local pid:
pubs:638853
Deposit date:
2016-08-17

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