Journal article
Measurement error, time lag, unmeasured confounding: considerations for longitudinal estimation of the effect of a mediator in randomised clinical trials
- Abstract:
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Clinical trials are expensive and time-consuming and so should also be used to study how treatments work. This would allow evaluation of theoretical treatment models and refinement and improvement of treatments. Treatment processes can be studied using mediation analysis. Randomised treatment makes some of the assumptions of mediation models plausible, but the mediator – outcome relationship remains one that can be subject to bias. In addition, mediation is assumed to be a temporally ordered ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Department for Work and Pensions
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Medical Research Council
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Department for Health for England
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The Scottish Chief Scientist Office
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Bibliographic Details
- Publisher:
- SAGE Publications Publisher's website
- Journal:
- Statistical Methods in Medical Research
- Publication date:
- 2016-09-19
- Acceptance date:
- 2016-08-04
- DOI:
- EISSN:
-
1477-0334
- ISSN:
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0962-2802 and 1477-0334
- Source identifiers:
-
638853
- EISBN:
Item Description
- Keywords:
- Pubs id:
-
pubs:638853
- UUID:
-
uuid:e2cb5c9a-3661-4a84-be5e-816e453eea9b
- Local pid:
- pubs:638853
- Deposit date:
- 2016-08-17
Terms of use
- Copyright holder:
- Goldsmith et al
- Copyright date:
- 2016
- Notes:
- © The Author(s) 2016. This is the accepted manuscript version of the article. The final version is available online from SAGE at: [10.1177/0962280216666111]
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