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Atomic resolution insight into host cell recognition by Toxoplasma gondii.

Abstract:

The obligate intracellular parasite Toxoplasma gondii, a member of the phylum Apicomplexa that includes Plasmodium spp., is one of the most widespread parasites and the causative agent of toxoplasmosis. Micronemal proteins (MICs) are released onto the parasite surface just before invasion of host cells and play important roles in host cell recognition, attachment and penetration. Here, we report the atomic structure for a key MIC, TgMIC1, and reveal a novel cell-binding motif called the micro...

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Publication status:
Published

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Publisher copy:
10.1038/sj.emboj.7601704

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
The EMBO journal
Volume:
26
Issue:
11
Pages:
2808-2820
Publication date:
2007-06-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:e2c288f7-9242-45aa-acac-35171492ac74
Source identifiers:
72830
Local pid:
pubs:72830

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