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Common variants associated with plasma triglycerides and risk for coronary artery disease

Abstract:

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10 -8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein chol...

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Publisher copy:
10.1038/ng.2795

Authors


Willer, CJ More by this author
Schmidt, EM More by this author
Sengupta, S More by this author
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Journal:
Nature Genetics
Volume:
45
Issue:
11
Pages:
1345-1353
Publication date:
2013-11-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:e29c3de1-1f61-43fd-8210-590abccbda7b
Source identifiers:
439184
Local pid:
pubs:439184
Language:
English

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