The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.

Journal article

Thymic output is a dynamic process, with high activity at birth punctuated by transient periods of involution during infection. Interferon-α (IFN-α) is a critical molecular mediator of pathogen-induced thymic involution, yet despite the importance of thymic involution, relatively little is known about the molecular integrators that establish sensitivity. Here we found that the microRNA network dependent on the endoribonuclease Dicer, and specifically microRNA miR-29a, was critical for diminis...

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Authors: Papadopoulou, A; Dooley, J; Linterman, M; Pierson, W; Ucar, O

• Publication status: Published
• Journal: Nature immunology
• Volume: 13
• Issue: 2
• Pages: 181-187
• Publication date: 2012-02-01
• DOI: 10.1038/ni.2193
• EISSN: 1529-2916
• ISSN: 1529-2908
• Language: English
• Keywords: Receptor, Interferon alpha-beta; Animals; Female; Male; MicroRNAs; Thymus Gland; Forkhead Transcription Factors; DEAD-box RNA Helicases; Ribonuclease III; Arthritis; Mice