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Subcellular targeting analysis of SDR-type hydroxysteroid dehydrogenases.

Abstract:

Most mammalian hydroxysteroid dehydrogenases known thus far belong to the protein superfamilies of short-chain dehydrogenases/reductases (SDR) and aldo-keto reductases (AKR). Whereas members of the AKR family are soluble, cytoplasmic enzymes, SDR-type hydroxysteroid dehydrogenases are also located to other subcellular compartments, i.e. endoplasmic reticulum, mitochondria or peroxisomes. Differential localization might play an important role in influencing the reaction direction of hydroxy de...

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Authors


Filling, C More by this author
Shafqat, N More by this author
Mårtensson, E More by this author
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Journal:
Molecular and cellular endocrinology
Volume:
171
Issue:
1-2
Pages:
99-101
Publication date:
2001-01-05
DOI:
EISSN:
1872-8057
ISSN:
0303-7207
URN:
uuid:e2856c2b-4c78-406d-8ca8-7915fc3e97d6
Source identifiers:
108630
Local pid:
pubs:108630

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