Subcellular targeting analysis of SDR-type hydroxysteroid dehydrogenases.

Journal article

Most mammalian hydroxysteroid dehydrogenases known thus far belong to the protein superfamilies of short-chain dehydrogenases/reductases (SDR) and aldo-keto reductases (AKR). Whereas members of the AKR family are soluble, cytoplasmic enzymes, SDR-type hydroxysteroid dehydrogenases are also located to other subcellular compartments, i.e. endoplasmic reticulum, mitochondria or peroxisomes. Differential localization might play an important role in influencing the reaction direction of hydroxy de...

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Authors: Filling, C; Wu, X; Shafqat, N; Hult, M; Mårtensson, E

• Journal: Molecular and cellular endocrinology
• Volume: 171
• Issue: 1-2
• Pages: 99-101
• Publication date: 2001-01-01
• DOI: 10.1016/s0303-7207(00)00419-6
• EISSN: 1872-8057
• ISSN: 0303-7207
• Language: English
• Keywords: Green Fluorescent Proteins; Microscopy, Fluorescence; Endoplasmic Reticulum; Transfection; Luminescent Proteins; Cell Membrane; 11-beta-Hydroxysteroid Dehydrogenases; Sequence Alignment; Subcellular Fractions; Hydroxysteroid Dehydrogenases; Peroxisomes; Animals; Recombinant Fusion Proteins; Humans; Peptide Fragments; Isoenzymes; Molecular Sequence Data; Amino Acid Sequence; COS Cells; Mitochondria