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Prolonged cortical silent period but normal sensorimotor plasticity in spinocerebellar ataxia 6.

Abstract:

Spinocerebellar ataxia 6 (SCA6) is a hereditary disease characterized by a trinucleotide repeat expansion in the CACNA1A gene and late-onset bilateral cerebellar atrophy. It is unclear if there is significant pathology outside of the cerebellum. We used transcranial magnetic stimulation to assess sensorimotor cortical circuits and cortical plasticity in 8 SCA6 patients and 8 age-matched controls. Behavioral performance was assessed using a rhythmic tapping task. Neurophysiological measures of...

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Publisher copy:
10.1002/mds.21847

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Journal:
Movement disorders : official journal of the Movement Disorder Society
Volume:
23
Issue:
3
Pages:
378-385
Publication date:
2008-02-05
DOI:
EISSN:
1531-8257
ISSN:
0885-3185
URN:
uuid:e27f0a7f-48e1-4234-9b28-1f5bbdc37ab6
Source identifiers:
243257
Local pid:
pubs:243257

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