Short-term synaptic plasticity, simulation of nerve terminal dynamics, and the effects of protein kinase C activation in rat hippocampus.

Journal article

Phorbol esters are hypothesised to produce a protein kinase C (PKC)-dependent increase in the probability of transmitter release via two mechanisms: facilitation of vesicle fusion or increases in synaptic vesicle number and replenishment. We used a combination of electrophysiology and computer simulation to distinguish these possibilities. We constructed a stochastic model of the presynaptic contacts between a pair of hippocampal pyramidal cells that used biologically realistic processes and ...

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Authors: Brager, D; Capogna, M; Thompson, S

• Journal: J Physiol
• Volume: 541
• Issue: Pt 2
• Pages: 545-559
• Publication date: 2002-06-01
• DOI: 10.1113/jphysiol.2001.015842
• ISSN: 0022-3751
• Language: English
• Keywords: Animals; Nerve Endings; Phorbol Esters; Rats; Synapses; Protein Kinase C; Hippocampus; Excitatory Postsynaptic Potentials; Algorithms; Neuronal Plasticity; Organ Culture Techniques; Enzyme Activation; Electric Stimulation; Exocytosis; Models, Neurological