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Short-term synaptic plasticity, simulation of nerve terminal dynamics, and the effects of protein kinase C activation in rat hippocampus.

Abstract:

Phorbol esters are hypothesised to produce a protein kinase C (PKC)-dependent increase in the probability of transmitter release via two mechanisms: facilitation of vesicle fusion or increases in synaptic vesicle number and replenishment. We used a combination of electrophysiology and computer simulation to distinguish these possibilities. We constructed a stochastic model of the presynaptic contacts between a pair of hippocampal pyramidal cells that used biologically realistic processes and ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
J Physiol
Volume:
541
Issue:
Pt 2
Pages:
545-559
Publication date:
2002-06-01
DOI:
ISSN:
0022-3751
URN:
uuid:e278abd3-164c-4b76-a7c8-d6c51cbb090a
Source identifiers:
329226
Local pid:
pubs:329226

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