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Journal article

Striking oxygen sensitivity of the peptidylglycine a-amidating monooxygenase (PAM) in neuroendocrine cells

Abstract:

Interactions between biological pathways and molecular oxygen require robust mechanisms for detecting and responding to changes in cellular oxygen availability, to support oxygen homeostasis. Peptidylglycine α-amidating monooxygenase (PAM) catalyzes a two-step reaction resulting in the C-terminal amidation of peptides, a process important for their stability and biological activity. Here we show that in human, mouse, and insect cells, peptide amidation is exquisitely sensitive to hypoxia. Dif...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.m115.667246

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
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Wellcome Trust More from this funder
Ludwig Institute for Cancer Research More from this funder
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
290
Issue:
41
Pages:
24891-24901
Publication date:
2015-10-09
Acceptance date:
2015-08-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
542865
Language:
English
Keywords:
Pubs id:
pubs:542865
UUID:
uuid:e2679406-cda8-40b2-a677-18afa45cfa06
Local pid:
pubs:542865
Deposit date:
2016-02-23

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