Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission

Journal article

Optogenetic silencing using light-driven ion fluxes permits rapid and effective inhibition of neural activity. Using rodent hippocampal neurons, we found that silencing activity with a chloride pump can increase the probability of synaptically evoked spiking after photoactivation; this did not occur with a proton pump. This effect can be accounted for by changes to the GABA A receptor reversal potential and demonstrates an important difference between silencing strategies. © 2012 Nature America, Inc. All rights reserved.

Authors: Raimondo, J; Kay, L; Ellender, T; Akerman, C

• Journal: Nature Neuroscience
• Volume: 15
• Issue: 8
• Pages: 1102-1104
• Publication date: 2012-08-01
• DOI: 10.1038/nn.3143
• EISSN: 1546-1726
• ISSN: 1097-6256
• Language: English