Journal article icon

Journal article

Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission

Abstract:
Optogenetic silencing using light-driven ion fluxes permits rapid and effective inhibition of neural activity. Using rodent hippocampal neurons, we found that silencing activity with a chloride pump can increase the probability of synaptically evoked spiking after photoactivation; this did not occur with a proton pump. This effect can be accounted for by changes to the GABA A receptor reversal potential and demonstrates an important difference between silencing strategies. © 2012 Nature America, Inc. All rights reserved.

Actions


Access Document


Publisher copy:
10.1038/nn.3143

Authors


Raimondo, JV More by this author
Ellender, TJ More by this author
Akerman, CJ More by this author
Journal:
Nature Neuroscience
Volume:
15
Issue:
8
Pages:
1102-1104
Publication date:
2012-08-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:e2677ca9-d3a3-489a-8068-854ca4f7f86a
Source identifiers:
348987
Local pid:
pubs:348987
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP