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Stereoselective and region-specific induction of immediate early gene expression in rat parietal cortex by blockade of neurokinin 1 receptors.

Abstract:

Antagonists at neurokinin 1 (NK1) receptors are attracting attention as potential treatments for depressive states in light of their actions in behavioural models predictive of antidepressant properties, their modulation of corticolimbic monoaminergic transmission, and their influence upon neural plasticity. Here, we evaluated the influence of NK1 receptor blockade upon two immediate early genes, Arc and c-fos, implicated in mechanisms of synaptic plasticity. Administration of the selective N...

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Publication status:
Published

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Publisher copy:
10.1177/0269881105059327

Authors


Sartori, SB More by this author
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Journal:
Journal of psychopharmacology (Oxford, England)
Volume:
20
Issue:
4
Pages:
570-576
Publication date:
2006-07-05
DOI:
EISSN:
1461-7285
ISSN:
0269-8811
URN:
uuid:e24e8cd6-fb6e-4fd5-aeae-4ead7233f41d
Source identifiers:
185135
Local pid:
pubs:185135

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