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DNA repair factor APLF is a histone chaperone.

Abstract:

Poly(ADP-ribosyl)ation plays a major role in DNA repair, where it regulates chromatin relaxation as one of the critical events in the repair process. However, the molecular mechanism by which poly(ADP-ribose) modulates chromatin remains poorly understood. Here we identify the poly(ADP-ribose)-regulated protein APLF as a DNA-damage-specific histone chaperone. APLF preferentially binds to the histone H3/H4 tetramer via its C-terminal acidic motif, which is homologous to the motif conserved in t...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Molecular cell
Volume:
41
Issue:
1
Pages:
46-55
Publication date:
2011-01-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:e24931ee-a3a2-4bed-8e56-12b1ab8c881d
Source identifiers:
376187
Local pid:
pubs:376187

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