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A mathematical model of liver cell aggregation in vitro.

Abstract:

The behavior of mammalian cells within three-dimensional structures is an area of intense biological research and underpins the efforts of tissue engineers to regenerate human tissues for clinical applications. In the particular case of hepatocytes (liver cells), the formation of spheroidal multicellular aggregates has been shown to improve cell viability and functionality compared to traditional monolayer culture techniques. We propose a simple mathematical model for the early stages of this...

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Publication status:
Published

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Publisher copy:
10.1007/s11538-008-9387-1

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Shakesheff, KM More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Journal:
Bulletin of mathematical biology
Volume:
71
Issue:
4
Pages:
906-930
Publication date:
2009-05-05
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
URN:
uuid:e23ac2b2-07d9-45c1-9508-39f276d546f5
Source identifiers:
199834
Local pid:
pubs:199834

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