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Adrenaline and extracellular ATP switch between two modes of acid extrusion in the guinea-pig ventricular myocyte.

Abstract:

1. Intracellular pH (pHi) was recorded in isolated guinea-pig ventricular myocytes using the pH-sensitive fluoroprobe, carboxy-SNARF-1 (carboxy-seminaphthorhodafluor). 2. Addition and removal of 10 mM NH4Cl was used to induce an intracellular acid load in a myocyte perfused with HCO3(-)-buffered solution containing amiloride. Under these conditions, subsequent pHi recovery is known to rely upon Na(+)-HCO3- co-transport into the cell. The application of 0.5-5 microM adrenaline resulted in an i...

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Publication status:
Published

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Authors


Lagadic-Gossmann, D More by this author
Vaughan-Jones, RD More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
The Journal of physiology
Volume:
458
Pages:
385-407
Publication date:
1992-12-05
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:e2119324-4566-4dad-a5cf-8eed3f0008ff
Source identifiers:
312258
Local pid:
pubs:312258

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