Increased gametocytemia after treatment: an early parasitological indicator of emerging sulfadoxine-pyrimethamine resistance in falciparum malaria.

Conference item

BACKGROUND: Although malaria treatment aims primarily to eliminate the asexual blood stages that cause illness, reducing the carriage of gametocytes is critical for limiting malaria transmission and the spread of resistance. METHODS: Clinical and parasitological responses to the fixed-dose combination of sulfadoxine and pyrimethamine in patients with uncomplicated falciparum malaria were assessed biannually since implementation of this treatment policy in 1998 in Mpumalanga Province, South A...

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Authors: Barnes, K; Little, F; Mabuza, A; Mngomezulu, N; Govere, J

• Publication status: Published
• Host title: The Journal of infectious diseases
• Volume: 197
• Issue: 11
• Pages: 1605-1613
• Publication date: 2008-06-01
• Event location: United States
• DOI: 10.1086/587645
• EISSN: 1537-6613
• ISSN: 0022-1899
• Keywords: Plasmodium falciparum; Animals; Adult; Malaria, Falciparum; Treatment Outcome; Humans; South Africa; Mutation, Missense; Drug Resistance; Dihydropteroate Synthase; Protozoan Proteins; Sulfadoxine; Polymerase Chain Reaction; Drug Combinations; Antimalarials; Time Factors; Area Under Curve; Female; Child; Male; Parasitemia; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Adolescent; Polymorphism, Genetic