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Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency.

Abstract:

Common variable immunodeficiency (CVID) is an heterogeneous syndrome characterized by decreased levels of serum Ig and recurrent bacterial infection. Here, we were interested to study whether a qualitative defect of the affinity Ab maturation process could be combined to the low level of serum Ig in a cohort of 38 CVID patients. For this, we designed a novel and rapid screening test for the detection of hypomutated V gene expressed by memory B cells. This test delineated a subset of 9/38 (23%...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.165.8.4725

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
165
Issue:
8
Pages:
4725-4730
Publication date:
2000-10-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:e1f43aa0-5c4a-4b30-960f-d073c7102a25
Source identifiers:
66572
Local pid:
pubs:66572

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