- Abstract:
-
Common variable immunodeficiency (CVID) is an heterogeneous syndrome characterized by decreased levels of serum Ig and recurrent bacterial infection. Here, we were interested to study whether a qualitative defect of the affinity Ab maturation process could be combined to the low level of serum Ig in a cohort of 38 CVID patients. For this, we designed a novel and rapid screening test for the detection of hypomutated V gene expressed by memory B cells. This test delineated a subset of 9/38 (23%...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4049/jimmunol.165.8.4725
-
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 165
- Issue:
- 8
- Pages:
- 4725-4730
- Publication date:
- 2000-10-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:e1f43aa0-5c4a-4b30-960f-d073c7102a25
- Source identifiers:
-
66572
- Local pid:
- pubs:66572
- Language:
- English
- Keywords:
- Copyright date:
- 2000
Journal article
Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency.
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