Journal article
Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency.
- Abstract:
-
Common variable immunodeficiency (CVID) is an heterogeneous syndrome characterized by decreased levels of serum Ig and recurrent bacterial infection. Here, we were interested to study whether a qualitative defect of the affinity Ab maturation process could be combined to the low level of serum Ig in a cohort of 38 CVID patients. For this, we designed a novel and rapid screening test for the detection of hypomutated V gene expressed by memory B cells. This test delineated a subset of 9/38 (23%...
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- Publication status:
- Published
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- Publisher copy:
- 10.4049/jimmunol.165.8.4725
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Authors
Bibliographic Details
- Journal:
- Journal of Immunology
- Volume:
- 165
- Issue:
- 8
- Pages:
- 4725-4730
- Publication date:
- 2000-10-01
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Source identifiers:
-
66572
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:66572
- UUID:
-
uuid:e1f43aa0-5c4a-4b30-960f-d073c7102a25
- Local pid:
- pubs:66572
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2000
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