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A multiple timescale analysis of a mathematical model of the Wnt/β−catenin signalling pathway

Abstract:

The Wnt signalling pathway is involved in stem cell maintenance, differentiation and tissue development. Its disregulation has also been implicated in many cancers. β-catenin is a protein that regulates both transcription of many genes and cell-cell adhesion; in response to an external Wnt stimulus the intracellular levels of β-catenin are controlled by the proteins which make up the Wnt/β-catenin signalling pathway. In this paper we present a systematic asymptotic analysis of an existing mod...

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Publisher copy:
10.1007/s00285-009-0262-y

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Journal:
Journal of mathematical biology
Volume:
60
Issue:
1
Pages:
131-160
Publication date:
2009-09-01
DOI:
URN:
uuid:e1f09c2e-7e5b-4106-b5b2-c8508ccf7290
Local pid:
cs:5032

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