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Thesis

An autophagy-related single nucleotide polymorphism in artemisinin-resistant Plasmodium falciparum

Abstract:

Artemisinin-resistant Plasmodium falciparum parasites have been reported in the Greater Mekong Subregion since 2007. Artemisinin combination therapy (ACT) is the mainstay of antimalarial treatment and is responsible for decreases in malaria-related morbidity and mortality over the past fifteen years. The slowed parasite clearance rates following ACT indicates resistance to artemisinin derivatives. This resistance places increasing selective pressure for variants or traits that confer resis...

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Department:
University of Oxford
Role:
Author

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Department:
University of Oxford
Role:
Supervisor
Department:
University of Oxford
Role:
Supervisor
Department:
National Institutes of Health
Role:
Supervisor
Department:
University of Oxford
Role:
Examiner
Department:
Wellcome Sanger Institute
Role:
Examiner
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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