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Development of polycystic ovary syndrome: involvement of genetic and environmental factors.

Abstract:

We have recently proposed that polycystic ovary syndrome (PCOS) has its origin in fetal life. This hypothesis is based on data from animal models (rhesus monkey or sheep that have been exposed prenatally to high doses of androgen) and is supported by clinical studies. It is suggested that, in human females, exposure to excess androgen, at any stage from fetal development of the ovary to the onset of puberty, leads to many of the characteristic features of PCOS, including abnormalities of lute...

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Publication status:
Published

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Authors


McCarthy, MI More by this author
Volume:
29
Issue:
1
Pages:
278-285
Publication date:
2006-02-05
DOI:
EISSN:
1365-2605
ISSN:
0105-6263
URN:
uuid:e1ce4096-324e-43a4-b95a-39b0d076d7ba
Source identifiers:
25774
Local pid:
pubs:25774

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