Antidepressant drug action: a neuropsychological perspective.
Early effects of antidepressants on emotional processing can be seen in healthy volunteers and in depressed patients with a consistent pattern of effect in behavioral and neural (fMRI) outcome measures. This early positive-biasing of emotional processing could help explain why antidepressant drug treatments have a delayed clinical onset of action, but suggest that the delay may occur because of the need for further psychological rather than neurophysiological processing. The identification of...Expand abstract
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