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Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria.

Abstract:

Background

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functional domains called domain cassettes. Despite their tremendous diversity there is compelling evidence that a restricted subset of PfEMP1s is expressed in severe disease. In this study a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12936-016-1296-4

Authors


Noviyanti, R More by this author
Trianty, L More by this author
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Funding agency for:
Price, RN
Australian Agency for International Development More from this funder
Victorian State Government More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Malaria journal Journal website
Volume:
15
Issue:
1
Pages:
258
Publication date:
2016-05-05
DOI:
EISSN:
1475-2875
URN:
uuid:e19cf037-b15d-48d5-b296-3fbe5d9a94f7
Source identifiers:
619914
Local pid:
pubs:619914
Language:
English
Keywords:

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