Journal article icon

Journal article

Inhibition of JNK by overexpression of the JNL binding domain of JIP-1 prevents apoptosis in sympathetic neurons.

Abstract:

Studies in non-neuronal cells show that c-Jun N-terminal kinases (JNK) play a key role in apoptotic cell death. In some neurons JNK is also thought to initiate cell death by the activation of c-Jun. JNK inhibition has been achieved pharmacologically by inhibiting upstream kinases, but there has been no direct demonstration that inhibition of JNK can prevent neuronal death. We have therefore examined whether the JNK binding domain (JBD) of JNK-interacting protein-1 (JIP-1, a scaffold protein a...

Expand abstract

Actions


Access Document


Publisher copy:
10.1074/jbc.c000815200

Authors


Harding, TC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Bienemann, A More by this author
Haywood, D More by this author
Dickens, M More by this author
Expand authors...
Journal:
The Journal of biological chemistry
Volume:
276
Issue:
7
Pages:
4531-4534
Publication date:
2001-02-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:e19bbd44-7b44-476c-a674-b4ae5f9837b3
Source identifiers:
111201
Local pid:
pubs:111201

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP