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Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages

Abstract:

The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells. Here, we analyze genome organization in the P. falciparum and P. vivax transmission stages. Major changes occur in the localization and interactions of genes involved in pathoge...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-04295-5

Authors


Bunnik, EM More by this author
Varoquaux, N More by this author
Batugedara, G More by this author
Prudhomme, J More by this author
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Wellcome Trust More from this funder
French National Research Agency More from this funder
Miller Institute for Basic Research in Science More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
1910
Publication date:
2018-05-15
Acceptance date:
2018-04-18
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:848133
URN:
uri:e194fc49-4801-4e4a-8f6a-cfa15860a436
UUID:
uuid:e194fc49-4801-4e4a-8f6a-cfa15860a436
Local pid:
pubs:848133
Language:
English
Keywords:

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