A randomized comparison of artesunate-atovaquone-proguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy.

Journal article

BACKGROUND: There is no safe, practical, and effective treatment for pregnant women infected with multidrug-resistant Plasmodium falciparum. METHODS: We recruited pregnant Karen women in the second or third trimesters of pregnancy who had uncomplicated falciparum malaria for a randomized, open-label trial with a restricted sequential trial design of 7 days of supervised quinine (SQ7) versus 3 days of artesunate-atovaquone-proguanil (AAP). RESULTS: Eight-one pregnant women entered the study b...

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Authors: Mcgready, R; Ashley, E; Moo, E; Cho, T; Barends, M

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 192
• Issue: 5
• Pages: 846-853
• Publication date: 2005-09-01
• DOI: 10.1086/432551
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Plasmodium falciparum; Animals; Pregnancy Complications, Parasitic; Adult; Infant; Malaria, Falciparum; Quinine; Parasitemia; Adolescent; Naphthoquinones; Artemisinins; Proguanil; Thailand; Antimalarials; Sesquiterpenes; Anemia; Pregnancy Outcome; Female; Humans; Infant, Newborn; Pregnancy; Atovaquone