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Low levels of peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) cells are found in HIV and HIV/TB co-infection

Abstract:

Background: High expression of CD161 on CD8+ T cells is associated with a population of cells thought to play a role in mucosal immunity. We wished to investigate this subset in an HIV and Mycobacterium tuberculosis (MTB) endemic African setting. Methods: A flow cytometric approach was used to assess the frequency and phenotype of CD161++CD8+ T cells. 80 individuals were recruited for cross-sectional analysis: controls (n = 18), latent MTB infection (LTBI) only (n = 16), pulmonary tuberculosi...

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Authors


Akilimali, NA More by this author
Govender, P More by this author
Sullivan, ZA More by this author
Cosgrove, C More by this author
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Journal:
PLoS ONE
Volume:
8
Issue:
12
Publication date:
2013-12-31
DOI:
EISSN:
1932-6203
URN:
uuid:e18ad20f-32ad-462c-9fff-71ca334df0ae
Source identifiers:
459629
Local pid:
pubs:459629
Language:
English

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