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Meta-analysis of expression of l(3)mbt tumor-associated germline genes supports the model that a soma-to-germline transition is a hallmark of human cancers.

Abstract:

Evidence is starting to emerge indicating that tumorigenesis in metazoans involves a soma-to-germline transition, which may contribute to the acquisition of neoplastic characteristics. Here, we have meta-analyzed gene expression profiles of the human orthologs of Drosophila melanogaster germline genes that are ectopically expressed in l(3)mbt brain tumors using gene expression datasets derived from a large cohort of human tumors. We find these germline genes, some of which drive oncogenesis i...

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Publisher copy:
10.1002/ijc.28577

Authors


Publisher:
Wiley-Liss Inc.
Journal:
International journal of cancer. Journal international du cancer
Volume:
134
Issue:
10
Pages:
2359-2365
Publication date:
2014-05-05
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
URN:
uuid:e18a7657-3bfc-477f-adea-b552f1d9dd56
Source identifiers:
491070
Local pid:
pubs:491070

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