The Isw2 chromatin-remodeling ATPase cooperates with the Fkh2 transcription factor to repress transcription of the B-type cyclin gene CLB2.

Journal article

Forkhead (Fkh) transcription factors influence cell death, proliferation, and differentiation and the cell cycle. In Saccharomyces cerevisiae, Fkh2 both activates and represses transcription of CLB2, encoding a B-type cyclin. CLB2 is expressed during G(2)/M phase and repressed during G(1). Fkh2 recruits the coactivator Ndd1, an interaction which is promoted by Clb2/Cdk1-dependent phosphorylation of Ndd1, suggesting that CLB2 is autoregulated. Ndd1 is proposed to function by antagonizing Fkh2-...

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Authors: Sherriff, J; Kent, N; Mellor, J

• Publication status: Published
• Journal: Molecular and cellular biology
• Volume: 27
• Issue: 8
• Pages: 2848-2860
• Publication date: 2007-04-01
• DOI: 10.1128/mcb.01798-06
• EISSN: 1098-5549
• ISSN: 0270-7306
• Language: English
• Keywords: Chromatin Assembly and Disassembly; Repressor Proteins; Cell Cycle; Transcription Factors; Protein Binding; Saccharomyces cerevisiae Proteins; Promoter Regions, Genetic; Nucleosomes; Transcription, Genetic; Forkhead Transcription Factors; Gene Deletion; Genes, Lethal; Cyclin B; Suppression, Genetic; Saccharomyces cerevisiae; Cell Cycle Proteins; Adenosine Triphosphatases; Gene Expression Regulation, Fungal