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Fool's gold: Why imperfect reference tests are undermining the evaluation of novel diagnostics: a reevaluation of 5 diagnostic tests for leptospirosis.

Abstract:

BACKGROUND: We observed that some patients with clinical leptospirosis supported by positive results of rapid tests were negative for leptospirosis on the basis of our diagnostic gold standard, which involves isolation of Leptospira species from blood culture and/or a positive result of a microscopic agglutination test (MAT). We hypothesized that our reference standard was imperfect and used statistical modeling to investigate this hypothesis. METHODS: Data for 1652 patients with suspected le...

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Publication status:
Published

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Publisher copy:
10.1093/cid/cis403

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
55
Issue:
3
Pages:
322-331
Publication date:
2012-08-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:e184fbb4-0e76-47f9-b145-f4c769ef4854
Source identifiers:
325217
Local pid:
pubs:325217

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