- Abstract:
-
BACKGROUND: We observed that some patients with clinical leptospirosis supported by positive results of rapid tests were negative for leptospirosis on the basis of our diagnostic gold standard, which involves isolation of Leptospira species from blood culture and/or a positive result of a microscopic agglutination test (MAT). We hypothesized that our reference standard was imperfect and used statistical modeling to investigate this hypothesis. METHODS: Data for 1652 patients with suspected le...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/cid/cis403
-
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- Journal:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Volume:
- 55
- Issue:
- 3
- Pages:
- 322-331
- Publication date:
- 2012-08-05
- DOI:
- EISSN:
-
1537-6591
- ISSN:
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1058-4838
- URN:
-
uuid:e184fbb4-0e76-47f9-b145-f4c769ef4854
- Source identifiers:
-
325217
- Local pid:
- pubs:325217
- Copyright date:
- 2012
Journal article
Fool's gold: Why imperfect reference tests are undermining the evaluation of novel diagnostics: a reevaluation of 5 diagnostic tests for leptospirosis.
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