- Abstract:
-
AIMS: The coordinated expression of the Notch ligands Delta-like 4 (Dll4) and Jagged (Jag)1 is believed to define appropriate endothelial sensitivity to vascular endothelial growth factor (VEGF). Preclinical data suggest that Dll4-Notch signalling may confer resistance to anti-VEGF therapy with bevacizumab, and Jag1 may antagonize Dll4-Notch. The aims of this study were to characterize the expression of Dll4 and Jag1 in primary glioblastomas. METHODS AND RESULTS: Immunohistochemistry was perf...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1365-2559.2011.04138.x
-
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- Journal:
- Histopathology
- Volume:
- 60
- Issue:
- 5
- Pages:
- 740-747
- Publication date:
- 2012-04-05
- DOI:
- EISSN:
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1365-2559
- ISSN:
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0309-0167
- URN:
-
uuid:e183d252-8d20-401e-b58c-61d03cc91a8f
- Source identifiers:
-
246304
- Local pid:
- pubs:246304
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma.
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