Journal article
Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma.
- Abstract:
-
AIMS: The coordinated expression of the Notch ligands Delta-like 4 (Dll4) and Jagged (Jag)1 is believed to define appropriate endothelial sensitivity to vascular endothelial growth factor (VEGF). Preclinical data suggest that Dll4-Notch signalling may confer resistance to anti-VEGF therapy with bevacizumab, and Jag1 may antagonize Dll4-Notch. The aims of this study were to characterize the expression of Dll4 and Jag1 in primary glioblastomas. METHODS AND RESULTS: Immunohistochemistry was perf...
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- Publication status:
- Published
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- Publisher copy:
- 10.1111/j.1365-2559.2011.04138.x
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Bibliographic Details
- Journal:
- Histopathology
- Volume:
- 60
- Issue:
- 5
- Pages:
- 740-747
- Publication date:
- 2012-04-01
- DOI:
- EISSN:
-
1365-2559
- ISSN:
-
0309-0167
- Source identifiers:
-
246304
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:246304
- UUID:
-
uuid:e183d252-8d20-401e-b58c-61d03cc91a8f
- Local pid:
- pubs:246304
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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