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Journal article

Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma.

Abstract:

AIMS: The coordinated expression of the Notch ligands Delta-like 4 (Dll4) and Jagged (Jag)1 is believed to define appropriate endothelial sensitivity to vascular endothelial growth factor (VEGF). Preclinical data suggest that Dll4-Notch signalling may confer resistance to anti-VEGF therapy with bevacizumab, and Jag1 may antagonize Dll4-Notch. The aims of this study were to characterize the expression of Dll4 and Jag1 in primary glioblastomas. METHODS AND RESULTS: Immunohistochemistry was perf...

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Publication status:
Published

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Journal:
Histopathology
Volume:
60
Issue:
5
Pages:
740-747
Publication date:
2012-04-05
DOI:
EISSN:
1365-2559
ISSN:
0309-0167
URN:
uuid:e183d252-8d20-401e-b58c-61d03cc91a8f
Source identifiers:
246304
Local pid:
pubs:246304

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