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Journal article

Common variants at 11p13 are associated with susceptibility to tuberculosis.

Abstract:
After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).
Publication status:
Published

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Publisher copy:
10.1038/ng.1080

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Journal:
Nature genetics
Volume:
44
Issue:
3
Pages:
257-259
Publication date:
2012-03-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:e182e08d-a9fd-44b3-a700-b8bcb6285145
Source identifiers:
313803
Local pid:
pubs:313803

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