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Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity

Abstract:
The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may provide a useful template for fragment-based drug design providing rapid access to novel antibacterial compound libraries. © 2010 Elsevier Ltd. All rights reserved.
Publication status:
Published

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Authors


Cowley, AR More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
TETRAHEDRON-ASYMMETRY
Volume:
21
Issue:
13-14
Pages:
1758-1770
Publication date:
2010-07-14
DOI:
EISSN:
1362-511X
ISSN:
0957-4166
URN:
uuid:e17c2b5b-2044-43c5-be45-839b70521cc3
Source identifiers:
71230
Local pid:
pubs:71230
Language:
English

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