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Glucokinase (GCK) and other susceptibility genes for beta-cell dysfunction: the candidate approach.

Abstract:

There are well-documented examples in the literature of where determining the genetic aetiology of a disorder has provided insights into important regulatory pathways and protein interactions, and, more recently, has led to improved treatment options for patients. The studies of monogenic forms of beta-cell dysfunction are no exception. Naturally occurring mutations in the gene for the beta-cell enzyme glucokinase (GCK) result in both hyper- and hypo-glycaemia. Over 200 mutations have been de...

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Publication status:
Published

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Publisher copy:
10.1042/bst0360306

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Journal:
Biochemical Society transactions
Volume:
36
Issue:
Pt 3
Pages:
306-311
Publication date:
2008-06-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:e1778676-8b8c-4c8c-859f-38d30c09471b
Source identifiers:
9453
Local pid:
pubs:9453

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