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Thesis

Some structural and biochemical studies of nucleic acids

Abstract:

In part I, the distribution of pyrimidine bases in ox spleen deoxyribonucleic acid (DNA) have been investigated by treating the freshly prepared nucleic acid with hydrochloric acid in the presence of ethyl mercaptan. By this means the purine bases ware cleaved and a polymeric mercaptalated deoxyribonucleic acid (MDNA) was obtained in which diethylmercaptal groups replaced the purines. The vicinal hydroxyl groups in acyclic mercaptalated residues rendered MDNA labile to alkaline scission. T...

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Peer review status:
Peer reviewed

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Department:
University of Oxford
Role:
Author
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Source identifiers:
601870494
UUID:
uuid:e16449d2-56d5-4add-b2fb-9121e345b4f0
Local pid:
polonsky:9:23
Deposit date:
2017-10-05

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