Thesis
Some structural and biochemical studies of nucleic acids
- Abstract:
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In part I, the distribution of pyrimidine bases in ox spleen deoxyribonucleic acid (DNA) have been investigated by treating the freshly prepared nucleic acid with hydrochloric acid in the presence of ethyl mercaptan. By this means the purine bases ware cleaved and a polymeric mercaptalated deoxyribonucleic acid (MDNA) was obtained in which diethylmercaptal groups replaced the purines. The vicinal hydroxyl groups in acyclic mercaptalated residues rendered MDNA labile to alkaline scission. T...
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- Peer review status:
- Peer reviewed
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(pdf, 25.7MB)
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Authors
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Source identifiers:
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601870494
Item Description
- UUID:
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uuid:e16449d2-56d5-4add-b2fb-9121e345b4f0
- Local pid:
- polonsky:9:23
- Deposit date:
- 2017-10-05
Terms of use
- Copyright holder:
- Ward, P; Ward, Peter Frank Villiers
- Copyright date:
- 1956
- Notes:
- This thesis was digitised thanks to the generosity of Dr Leonard Polonsky
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