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CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.

Abstract:

Adaptation of the T cell activation threshold may be one mechanism to control autoreactivity. To investigate its occurrence in vivo, we engineered a transgenic mouse model with increased TCR-dependent excitability by expressing a Zap70 gain-of-function mutant (ZAP-YEEI) in postselection CD8 thymocytes and T cells. Increased basal phosphorylation of the Zap70 substrate linker for activation of T cells was detected in ZAP-YEEI-bearing CD8 T cells. However, these cells were not activated, but ha...

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Publication status:
Published

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Authors


Marquez, ME More by this author
Ellmeier, W More by this author
Sanchez-Guajardo, V More by this author
Freitas, AA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
175
Issue:
11
Pages:
7388-7397
Publication date:
2005-12-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:e15da84d-fa63-49c2-9a56-a08fd5549054
Source identifiers:
18182
Local pid:
pubs:18182

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