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Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: Individual patient data meta-analysis of the LEAD program

Abstract:

Background Non-alcoholic fatty liver disease has reached epidemic proportions in type 2 diabetes (T2D). Glucagon-like peptide-1 analogues are licensed in T2D, yet little data exist on efficacy and safety in liver injury. Aim To assess the safety and efficacy of 26-week liraglutide on liver parameters in comparison with active-placebo. Methods Individual patient data meta-analysis was performed using patient-level data combined from six 26-week, phase-III, randomised controlled T2D trials, whi...

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Publisher copy:
10.1111/apt.12149

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Journal:
Alimentary Pharmacology and Therapeutics
Volume:
37
Issue:
2
Pages:
234-242
Publication date:
2013-01-05
DOI:
EISSN:
1365-2036
ISSN:
0269-2813
URN:
uuid:e15c3c99-c80a-4817-a60c-e85be12bc810
Source identifiers:
384799
Local pid:
pubs:384799
Language:
English

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