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High expression of V gamma 8 is a shared feature of human gamma delta T cells in the epithelium of the gut and in the inflamed synovial tissue.

Abstract:

We have analyzed the V-gene usage in gamma delta T cells of the human gut and joint by using a new mAb (B18) specific for V gamma 8 of human TCR-gamma delta+ T cells. The B18+ population constituted a minor subset of the gamma delta T cells in peripheral blood (PB) of healthy persons (6 +/- 5%) and only 1 of 35 gamma delta T cell clones analyzed was positive. In contrast, the B18+ subset was a dominant gamma delta T cell population among intraepithelial lymphocytes (IEL) derived from the huma...

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Publication status:
Published

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Authors


Söderström, K More by this author
Lundqvist, C More by this author
Grönberg, A More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
152
Issue:
12
Pages:
6017-6027
Publication date:
1994-06-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:e15c36b1-4502-4330-b31e-24829dd187f9
Source identifiers:
475987
Local pid:
pubs:475987

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