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Journal article

Transcriptional control of left-right patterning in cardiac development.

Abstract:

The heart develops from a simple left-right (L-R) symmetrical tube. Through a complex process of looping and remodelling, it becomes a highly L-R asymmetrical organ with distinct asymmetries in both morphology and function. Abnormal cardiac L-R patterning can result in a spectrum of defects that include, dextrocardia (a malposition of the heart to the right), isomerism of the atria (both atria being morphologically right-sided or left-sided), abnormal ventricular topology (e.g. the morphologi...

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Publication status:
Published

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Publisher copy:
10.1007/s00246-009-9610-3

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
Pediatric cardiology
Volume:
31
Issue:
3
Pages:
371-377
Publication date:
2010-04-05
DOI:
EISSN:
1432-1971
ISSN:
0172-0643
URN:
uuid:e1563d73-cce6-40f5-ba13-209b689660a5
Source identifiers:
105256
Local pid:
pubs:105256

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