Effect of short-term macrophage depletion in the development of posterior capsule opacification in rodents.

Journal article

AIM: To evaluate the role of macrophages in the development of posterior capsule opacification (PCO). METHODS: For this purpose, an extracapsular lens extraction was performed in 18 consecutive Sprague-Dawley rats. Animals were treated with liposomal clodronate (Cl(2)MDP-lip-treated group, n = 10) or phosphate-buffered saline (PBS) (control group, n = 8) 1 day preoperatively and on the first day postoperatively, and sacrificed 3 days postoperatively. Masked clinical, light microscopy and imm...

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Authors: Lois, N; Dawson, R; Townend, J; McKinnon, A; Smith, G

• Publication status: Published
• Journal: British journal of ophthalmology
• Volume: 92
• Issue: 11
• Pages: 1528-1533
• Publication date: 2008-11-01
• DOI: 10.1136/bjo.2007.130518
• EISSN: 1468-2079
• ISSN: 0007-1161
• Language: English
• Keywords: Macrophages; Animals; Rats; Liposomes; Phacoemulsification; Male; Epithelial Cells; Sodium Chloride; Lens Capsule, Crystalline; Cataract; Clodronic Acid; Rats, Sprague-Dawley; Disease Models, Animal