Global Phylogenomic Analysis of Nonencapsulated Streptococcus pneumoniae Reveals a Deep-Branching Classic Lineage That Is Distinct from Multiple Sporadic Lineages.

Journal article

The surrounding capsule of Streptococcus pneumoniae has been identified as a major virulence factor and is targeted by pneumococcal conjugate vaccines (PCV). However, nonencapsulated S. pneumoniae (non-Ec-Sp) have also been isolated globally, mainly in carriage studies. It is unknown if non-Ec-Sp evolve sporadically, if they have high antibiotic nonsusceptiblity rates and a unique, specific gene content. Here, whole-genome sequencing of 131 non-Ec-Sp isolates sourced from 17 different locatio...

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Authors: Hilty, M; Wüthrich, D; Salter, S; Engel, H; Campbell, S

• Journal: Genome biology and evolution
• Volume: 6
• Issue: 12
• Pages: 3281-3294
• Publication date: 2014-01-01
• DOI: 10.1093/gbe/evu263
• EISSN: 1759-6653
• Language: English
• Keywords: pneumococcal isolates; antibiotic nonsusceptibility; whole-genome sequencing; comparative genomics; integrative conjugative elements