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Conservation and diversity of influenza A H1N1 HLA-restricted T cell epitope candidates for epitope-based vaccines.

Abstract:

BACKGROUND: The immune-related evolution of influenza viruses is exceedingly complex and current vaccines against influenza must be reformulated for each influenza season because of the high degree of antigenic drift among circulating influenza strains. Delay in vaccine production is a serious problem in responding to a pandemic situation, such as that of the current H1N1 strain. Immune escape is generally attributed to reduced antibody recognition of the viral hemagglutinin and neuraminidas...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0008754

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Marques, ET More by this author
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Journal:
PloS one
Volume:
5
Issue:
1
Pages:
e8754
Publication date:
2010
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:e15483a4-1c0c-4b5e-8eaf-02a1d9293e83
Source identifiers:
46165
Local pid:
pubs:46165

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