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The inter-relationship of antigenic structure, thymus-independence and adjuvanticity. IV. A general model for B-cell induction.

Abstract:

Polymerized flagellin and E. coli lipopolysaccharide both express adjuvanticity in vivo and in vitro for responses to hapten conjugated to sheep erythrocytes, and hapten conjugated to soluble thymus-dependent antigens. In the case of erythrocyte-bound hapten, adjuvanticity is expressed in the absence of thymus-derived cells (T cells). However, in the case of responses to soluble thymus-dependent conjugates, carrier-specific T cells would appear to be necessary for adjuvanticity to be expresse...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Immunology
Volume:
28
Issue:
3
Pages:
509-522
Publication date:
1975-03-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:e152180e-96c8-4d5b-87c4-fe0b4af9071a
Source identifiers:
9315
Local pid:
pubs:9315

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