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How ATP inhibits the open K(ATP) channel.

Abstract:

ATP-sensitive potassium (K(ATP)) channels are composed of four pore-forming Kir6.2 subunits and four regulatory SUR1 subunits. Binding of ATP to Kir6.2 leads to inhibition of channel activity. Because there are four subunits and thus four ATP-binding sites, four binding events are possible. ATP binds to both the open and closed states of the channel and produces a decrease in the mean open time, a reduction in the mean burst duration, and an increase in the frequency and duration of the inter...

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Publication status:
Published

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Publisher copy:
10.1085/jgp.200709874

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
The Journal of general physiology
Volume:
132
Issue:
1
Pages:
131-144
Publication date:
2008-07-05
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
URN:
uuid:e14ec860-6a73-413d-af45-0de620bded6f
Source identifiers:
113420
Local pid:
pubs:113420

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