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Prolonged reduction of leukocyte membrane-associated Dectin-1 levels following beta-glucan administration.

Abstract:

Dectin-1 is the primary pattern recognition receptor for fungal glucans. Dectin-1 mediates the internalization and biological response to glucans. We examined the effect of i.v. or i.p. glucan phosphate (GP) administration on Dectin-1 membrane expression in murine peripheral blood leukocytes, splenocytes, bone marrow, and peritoneal cells from 3 h to 10 days after injection. Circulating leukocytes were also examined for uptake and internalization of glucans from the blood. Fluorescent-labeled...

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Publication status:
Published

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Publisher copy:
10.1124/jpet.106.102293

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
The Journal of pharmacology and experimental therapeutics
Volume:
318
Issue:
2
Pages:
540-546
Publication date:
2006-08-05
DOI:
EISSN:
1521-0103
ISSN:
0022-3565
URN:
uuid:e14a367e-14d2-4294-8524-f4aa9f8d91e2
Source identifiers:
18858
Local pid:
pubs:18858

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