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Bicaudal-D and its role in cargo sorting by microtubule-based motors.

Abstract:

Many cytoplasmic cargoes are transported along microtubules using dynein or kinesin molecular motors. As the sorting machinery of the cell needs to be tightly controlled, associated factors are employed to either recruit cargoes to motors or to regulate their activities. In the present review, we concentrate on the BicD (Bicaudal-D) protein, which has recently emerged as an essential element for transport of several important cargoes by the minus-end-directed motor cytoplasmic dynein. BicD wa...

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Publication status:
Published

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Publisher copy:
10.1042/bst0371066

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Biochemical Society transactions
Volume:
37
Issue:
Pt 5
Pages:
1066-1071
Publication date:
2009-10-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:e139fc62-40ef-41e3-bc92-1de8ad71120d
Source identifiers:
55388
Local pid:
pubs:55388

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